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Antimicrobial Strategies for Medical Devices

The challenges for implantable medical devices coatings is three fold – the coating should protect the device from the body, protect the body from the coated device and importantly without impairing the function of the body or the medical device. This is a very pertinent concept for antimicrobial medical devices.

The clinical problem for implantable medical devices has been known for sometime and various methodologies have been used to combat this problem. The price, both in terms of patient life and treatment cost, is having great effect on healthcare providers.

This talk will consider the clinical problems, the strategies employed to overcome medical device infections and will also discuss a new approach developed by BioInteractions Ltd, the AvertPlus™ Surface Enhance Antimicrobial Coating and reveal a new concept to treat medical device infections, Evolve™, this technology combines the advance dual function anti-thrombogenic and anti-platelet moiety with antimicrobial functionality.

Dr. Ajay Luthra

BioInteractions Ltd.

For my PhD I studied synthesis and characterisation of synthetic enzymes. My interest in biocompatible biomaterials came when I joined Oxford University as Senior Research Fellow working on implantable glucose sensors. I later joined Professor Dennis Chapman’s group at the Royal Free Hospital and become consultant to Biocompatibles Inc. My first proper job was as Head of Chemistry with Biomedical Sensors developing implantable sensors. In 1991 I progressed to start BioInteractions where I developed biocompatible biomaterials and I am co-inventor of 6 patents, which have been filed world wide. These patents have yielded 7 products for BioInteractions, which have been licensed to Medtronic, Covidien, B Braun and Others. I am Chairman of Royal Society Biomaterials Chemistry Division and Fellow of the Royal Society of Chemistry.